Dead effect 2 is also played same like the first version of this series (Dead Effect). Joystick controls the movement which is present on left of the screen. View and aim of player is controlled by moving finger across the touch screen. There are also present shortcuts for at once 90 degree movement from left to right. Usage of iron sights, reload, change of weapons, shoot and slow motion mode is used by the players with virtual touch buttons on the screen.
You can also change different controls through main menu control panel. Unlike first version player can fire in this new version of game automatically when rifle rests a little bit on the enemy. Weapons are also different from the basic version. Characters in this game like Gunnar Davis uses shotgun, Jan Frey uses melee weapons. Davis role is the same as in original game. This version includes multiplayer cooperation and also player to player.